Make the Chili Lime Sauce. Put all the ingredients in a food processor. Pulse for a few seconds and check. You want a slightly chunky texture. Pulse again if necessary. Set aside.
In a large bowl, combine the flour, garlic powder, onion powder, paprika, oregano, salt and pepper. Stir to combine. Add the beaten egg and beer. Whisk until smooth.
Heat about 2 inches of vegetable oil in a large deep sided skillet. Dip one shrimp in the batter, coating completely, and test the oil. If it sizzles immediately, it's ready. Coat shrimp in batter and drop one by one into the hot oil. Fry each side for about 2 minutes or until golden. Remove from oil with a large slotted spoon and place on paper towels. Repeat for all shrimp.
Best served immediately with the dipping sauce.
*A note on times provided: appliances vary, any prep and/or cook times provided are estimates only.